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On the surface of resorptive pitsthe mineral phase is solubilized in the clear acidiczone created at the ruffled border of osteoclasts,followed by resorption of protein matrix in thisarea by acid hydrolases secreted from osteoclasts.BPNs localise in the acidic zone under theosteoclasts due to their high affinity for Ca2+ ions.When Ca2+ ions are released from the bone surfacedue to high acidity, the BPNs are also releasedand are internalized into osteoclasts byendocytosis. This is not a new idea, having been discussed inacademic circles for the last few decades

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Leukemia, of course, is the kingpin of whiteblood cell pathology. Bonavita GJ, Pires LA, Wagshal AB, Cuello C, Mittleman RS, Greene TO, etal

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